The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4(+) T cells

TRPV1 is a Ca(2+)-permeable channel mostly studied as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here, we demonstrate that TRPV1 is functionally expressed in CD4(+) T cells where it acts as a non-store-operated Ca(2+) channel and contributes to T...

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Publicado no:Nat Immunol
Main Authors: Bertin, Samuel, Aoki-Nonaka, Yukari, de Jong, Petrus Rudolf, Nohara, Lilian L., Xu, Hongjian, Stanwood, Shawna R., Srikanth, Sonal, Lee, Jihyung, To, Keith, Abramson, Lior, Yu, Timothy, Han, Tiffany, Touma, Ranim, Li, Xiangli, González-Navajas, José M., Herdman, Scott, Corr, Maripat, Fu, Guo, Dong, Hui, Gwack, Yousang, Franco, Alessandra, Jefferies, Wilfred A., Raz, Eyal
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843825/
https://ncbi.nlm.nih.gov/pubmed/25282159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3009
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