Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase

BACKGROUND: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered a risk factor for the pathogenesis of cardiovascular diseases. Simvastatin, a lipid‐lowering drug with other pleiotropic effects, has been widely used for treatment of c...

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Publicat a:J Am Heart Assoc
Autors principals: Hsu, Chiao‐Po, Zhao, Jin‐Feng, Lin, Shing‐Jong, Shyue, Song‐Kun, Guo, Bei‐Chia, Lu, Tse‐Min, Lee, Tzong‐Shyuan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843600/
https://ncbi.nlm.nih.gov/pubmed/27091343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003327
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