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Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors
To study the development and function of “natural-arising” T regulatory (nTreg) cells, we developed a novel nTreg model on pure nonobese diabetic background using epigenetic reprogramming via somatic cell nuclear transfer. On RAG1-deficient background, we found that monoclonal FoxP3(+) CD4(+) Treg c...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4843484/ https://ncbi.nlm.nih.gov/pubmed/27044095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523664113 |
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