Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5). Although numerous proteins are modified by lysine succinylation, the physiological significance of ly...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sadhukhan, Sushabhan, Liu, Xiaojing, Ryu, Dongryeol, Nelson, Ornella D., Stupinski, John A., Li, Zhi, Chen, Wei, Zhang, Sheng, Weiss, Robert S., Locasale, Jason W., Auwerx, Johan, Lin, Hening
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843474/
https://ncbi.nlm.nih.gov/pubmed/27051063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519858113
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