Molecular basis for universal HLA-A*0201–restricted CD8(+) T-cell immunity against influenza viruses

Memory CD8(+) T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral proteins confer broad protection against distinct strains of influenza A virus (IAV). However, immune efficacy can be undermined by the emergence of escape mutants. To determine how T-cell receptor (TCR) c...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Valkenburg, Sophie A., Josephs, Tracy M., Clemens, E. Bridie, Grant, Emma J., Nguyen, Thi H. O., Wang, George C., Price, David A., Miller, Adrian, Tong, Steven Y. C., Thomas, Paul G., Doherty, Peter C., Rossjohn, Jamie, Gras, Stephanie, Kedzierska, Katherine
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843436/
https://ncbi.nlm.nih.gov/pubmed/27036003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603106113
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