NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell

Cancer stem cells (CSCs) are considered responsible for tumor initiation and chemoresistance. This study was aimed to investigate the possibility of targeting head neck squamous cell carcinoma (HNSCC) by NOTCH1 pathway inhibition and explore the synergistic effect of combining NOTCH inhibition with...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhao, Zhi-Li, Zhang, Lu, Huang, Cong-Fa, Ma, Si-Rui, Bu, Lin-Lin, Liu, Jian-Feng, Yu, Guang-Tao, Liu, Bing, Gutkind, J. Silvio, Kulkarni, Ashok B., Zhang, Wen-Feng, Sun, Zhi-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842967/
https://ncbi.nlm.nih.gov/pubmed/27108536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24704
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