Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

The putative channel-forming MII domains of the nicotinic, gamma-aminobutyric acid type A, and glycine receptors contain a highly conserved leucine residue. Mutation of this hydrophobic amino acid in the neuronal nicotinic receptor alpha 7 (Leu-247), reconstituted in Xenopus oocytes, modifies the io...

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Main Authors: Bertrand, D, Devillers-Thiéry, A, Revah, F, Galzi, J L, Hussy, N, Mulle, C, Bertrand, S, Ballivet, M, Changeux, J P
Formato: Artigo
Idioma:Inglês
Publicado: 1992
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC48429/
https://ncbi.nlm.nih.gov/pubmed/1741378
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