AB249. 15-oxospiramilactone reverses multidrug resistance in the Human Renal Cell Carcinoma by targeting ABCB1 through Inhibition of Wnt/β-catenin signaling

BACKGROUND: Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for Human Renal Cell Carcinoma. P-glycoprotein ABCB1 plays a major role in MDR of malignant cells and is regulated by various transcription factors, including Wnt/β-catenin /TCF4. We previously reported 15-oxos...

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Bibliographic Details
Published in:Transl Androl Urol
Main Authors: Shen, Tianyi, Yi, Xiaoming, Zhou, Wenquan
Format: Artigo
Language:Inglês
Published: AME Publishing Company 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842754/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tau.2016.s249
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