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Involvement of the Extrinsic and Intrinsic Pathways in Ultraviolet B-Induced Apoptosis of Corneal Epithelial Cells

The goal of this study was to elucidate the pathway by which UVB initiates efflux of K(+) and subsequently apoptosis in human corneal limbal epithelial (HCLE) cells. The initial focus of the study was on the extrinsic pathway involving Fas. HCLE cells transfected with Fas siRNA were exposed to 80–15...

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Publicado en:Exp Eye Res
Main Authors: Ubels, John L., Glupker, Courtney D., Schotanus, Mark P., Haarsma, Loren D.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842139/
https://ncbi.nlm.nih.gov/pubmed/26559338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2015.11.003
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