Ligase-4 deficiency causes distinctive immune abnormalities in asymptomatic individuals

PURPOSE: DNA Ligase 4 (LIG4) is a key factor in the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T receptor and immunoglobulin molecules. Defects in LIG4 result in a variable syndrome of growth retardation, pancytop...

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Publicado en:J Clin Immunol
Autores principales: Felgentreff, Kerstin, Baxi, Sachin N., Lee, Yu Nee, Dobbs, Kerry, Henderson, Lauren A., Csomos, Krisztian, Tsitsikov, Erdyni N., Armanios, Mary, Walter, Jolan E., Notarangelo, Luigi D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842108/
https://ncbi.nlm.nih.gov/pubmed/27063650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-016-0266-5
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