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Human RAG mutations: biochemistry and clinical implications
The recombination-activating gene 1 (RAG1) and RAG2 proteins initiate the V(D)J recombination process, which ultimately enables the generation of T cells and B cells with a diversified repertoire of antigen-specific receptors. Mutations of the RAG genes in humans are associated with a broad spectrum...
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| Publicado no: | Nat Rev Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5757527/ https://ncbi.nlm.nih.gov/pubmed/26996199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri.2016.28 |
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