Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells

Uterine smooth muscle cells remain quiescent throughout most of gestation, only generating spontaneous action potentials immediately prior to, and during, labor. This study presents a method that combines transcriptomics with biophysical recordings to characterise the conductance repertoire of these...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Atia, Jolene, McCloskey, Conor, Shmygol, Anatoly S., Rand, David A., van den Berg, Hugo A., Blanks, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841602/
https://ncbi.nlm.nih.gov/pubmed/27105427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004828
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