Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells

Uterine smooth muscle cells remain quiescent throughout most of gestation, only generating spontaneous action potentials immediately prior to, and during, labor. This study presents a method that combines transcriptomics with biophysical recordings to characterise the conductance repertoire of these...

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Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Atia, Jolene, McCloskey, Conor, Shmygol, Anatoly S., Rand, David A., van den Berg, Hugo A., Blanks, Andrew M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841602/
https://ncbi.nlm.nih.gov/pubmed/27105427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004828
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