A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

In the present study, we combined an in vitro 3D lung tumor model with an in silico model to optimize predictions of drug response based on a specific mutational background. The model is generated on a decellularized porcine scaffold that reproduces tissue-specific characteristics regarding extracel...

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Bibliografische gegevens
Gepubliceerd in:J Vis Exp
Hoofdauteurs: Göttlich, Claudia, Müller, Lena C., Kunz, Meik, Schmitt, Franziska, Walles, Heike, Walles, Thorsten, Dandekar, Thomas, Dandekar, Gudrun, Nietzer, Sarah L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MyJove Corporation 2016
Onderwerpen:
Bioengineering
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841364/
https://ncbi.nlm.nih.gov/pubmed/27077967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/53885
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