TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy

Primary central nervous system lymphoma (PCNSL) is an aggressive variant of diffuse large B-cell lymphoma (DLBCL) confined to the CNS. TP53 mutations (MUT-TP53) were investigated in the context of MIR34A/B/C- and DAPK promoter methylation status, and associated with clinical outcomes in PCNSL patien...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Munch-Petersen, Helga D., Asmar, Fazila, Dimopoulos, Konstantinos, Areškevičiūtė, Aušrinė, Brown, Peter, Girkov, Mia Seremet, Pedersen, Anja, Sjö, Lene D., Heegaard, Steffen, Broholm, Helle, Kristensen, Lasse S., Ralfkiaer, Elisabeth, Grønbæk, Kirsten
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840983/
https://ncbi.nlm.nih.gov/pubmed/27101868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0307-6
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