Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and Western countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD; nonetheless, the effect of inter-individual differe...

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Vydáno v:BMC Genomics
Hlavní autoři: Tryndyak, Volodymyr P., Han, Tao, Fuscoe, James C., Ross, Sharon A., Beland, Frederick A., Pogribny, Igor P.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840954/
https://ncbi.nlm.nih.gov/pubmed/27103143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2617-2
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