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Mechanism of SOS mutagenesis of UV-irradiated DNA: mostly error-free processing of deaminated cytosine.

We measured the kinetics of growth and mutagenesis of UV-irradiated DNA of phages S13 and lambda that were undergoing SOS repair; the kinetics strongly suggest that most of SOS mutagenesis arises from the deamination of cytosine in cyclobutane pyrimidine dimers, producing C----T transitions. This oc...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tessman, I, Liu, S K, Kennedy, M A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48408/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1741372/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.4.1159
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