Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells

The dramatic clinical benefit of immune checkpoint blockade for a fraction of cancer patients suggests the potential for further clinical benefit in a broader cancer patient population by combining immune checkpoint inhibitors with active immunotherapies. The anti-tumor efficacy of MVA-BN-HER2 poxvi...

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Veröffentlicht in:Cancer Immunol Immunother
Hauptverfasser: Foy, Susan P., Mandl, Stefanie J., dela Cruz, Tracy, Cote, Joseph J., Gordon, Evan J., Trent, Erica, Delcayre, Alain, Breitmeyer, James, Franzusoff, Alex, Rountree, Ryan B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840227/
https://ncbi.nlm.nih.gov/pubmed/26961085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1816-7
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