Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice

Poxvirus-based active immunotherapies mediate anti-tumor efficacy by triggering broad and durable Th1 dominated T cell responses against the tumor. While monotherapy significantly delays tumor growth, it often does not lead to complete tumor regression. It was hypothesized that the induced robust in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Foy, Susan P., Sennino, Barbara, dela Cruz, Tracy, Cote, Joseph J., Gordon, Evan J., Kemp, Felicia, Xavier, Veronica, Franzusoff, Alex, Rountree, Ryan B., Mandl, Stefanie J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765931/
https://ncbi.nlm.nih.gov/pubmed/26910562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150084
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados