Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice

Poxvirus-based active immunotherapies mediate anti-tumor efficacy by triggering broad and durable Th1 dominated T cell responses against the tumor. While monotherapy significantly delays tumor growth, it often does not lead to complete tumor regression. It was hypothesized that the induced robust in...

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Udgivet i:PLoS One
Main Authors: Foy, Susan P., Sennino, Barbara, dela Cruz, Tracy, Cote, Joseph J., Gordon, Evan J., Kemp, Felicia, Xavier, Veronica, Franzusoff, Alex, Rountree, Ryan B., Mandl, Stefanie J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765931/
https://ncbi.nlm.nih.gov/pubmed/26910562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150084
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