A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

Eukaryotes and prokaryotes possess fatty acid synthase (FAS) biosynthetic pathways that comprise iterative chain elongation, reduction, and dehydration reactions. The bacterial FASII pathway differs significantly from human FAS pathways and is a long-standing target for antibiotic development agains...

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Xehetasun bibliografikoak
Argitaratua izan da:J Mol Biol
Egile Nagusiak: Moynié, Lucile, Hope, Anthony G., Finzel, Kara, Schmidberger, Jason, Leckie, Stuart M., Schneider, Gunter, Burkart, Michael D., Smith, Andrew D., Gray, David W., Naismith, James H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840175/
https://ncbi.nlm.nih.gov/pubmed/26562505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.027
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