A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

Eukaryotes and prokaryotes possess fatty acid synthase (FAS) biosynthetic pathways that comprise iterative chain elongation, reduction, and dehydration reactions. The bacterial FASII pathway differs significantly from human FAS pathways and is a long-standing target for antibiotic development agains...

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Опубликовано в: :J Mol Biol
Главные авторы: Moynié, Lucile, Hope, Anthony G., Finzel, Kara, Schmidberger, Jason, Leckie, Stuart M., Schneider, Gunter, Burkart, Michael D., Smith, Andrew D., Gray, David W., Naismith, James H.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840175/
https://ncbi.nlm.nih.gov/pubmed/26562505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.027
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