A miR-221/222-mediated feedback loop maintains constitutive activation of NF-κB and STAT3 signaling in human colorectal cancers

BACKGROUND & AIMS: Constitutive activation of NF-κB and STAT3 pathways in human colorectal cancers links inflammation to CRC development and progression. However, the underlying mechanisms remain to be elucidated. Here we investigated the roles of miR-221 and miR-222 in regulating both NF-κB and...

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Publicado en:Gastroenterology
Main Authors: Liu, Sanhong, Sun, Xiaohua, Jiang, Yuhang, Liu, Zhanjie, Cao, Xinwei, Hou, Yingyong, Zhan, Yu, Tao, Yu, Wang, Lunshan, Xu, Chen, Chin, Eugene Y, Shi, Yufang, Siebenlist, Ulrich, Zhang, Xiaoren
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839969/
https://ncbi.nlm.nih.gov/pubmed/24931456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.06.006
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