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Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo

To achieve the great potential of siRNA based gene therapy, safe and efficient systemic delivery in vivo is essential. Here we report reductively responsive hydrogel nanoparticles with highly uniform size and shape for systemic siRNA delivery in vivo. “Blank” hydrogel nanoparticles with high aspect...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Ma, Da, Tian, Shaomin, Baryza, Jeremy, Luft, J. Christopher, DeSimone, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839470/
https://ncbi.nlm.nih.gov/pubmed/26287725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00054
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