Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish

Paclitaxel is a microtubule-stabilizing chemotherapeutic agent that is widely used in cancer treatment and in a number of curative and palliative regimens. Despite its beneficial effects on cancer, paclitaxel also damages healthy tissues, most prominently the peripheral sensory nervous system. The m...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lisse, Thomas S., Elias, Leah J., Pellegrini, Adriana D., Martin, Paige B., Spaulding, Emily L., Lopes, Olivia, Brochu, Elizabeth A., Carter, Erin V., Waldron, Ashley, Rieger, Sandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839466/
https://ncbi.nlm.nih.gov/pubmed/27035978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525096113
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