Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy

Anti-VEGF–based antiangiogenic drugs are designed to block tumor angiogenesis for treatment of cancer patients. However, anti-VEGF drugs produce off-tumor target effects on multiple tissues and organs and cause broad adverse effects. Here, we show that vasculatures in endocrine organs were more sens...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Yin, Yang, Yunlong, Hosaka, Kayoko, Huang, Guichun, Zang, Jingwu, Chen, Fang, Zhang, Yun, Samani, Nilesh J., Cao, Yihai
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839458/
https://ncbi.nlm.nih.gov/pubmed/27035988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601649113
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