Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants

Single-stranded DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high precision. We show that “oligo targeting” can be used effectively to study missense mutations in DNA mismatch repair (MMR) genes. Inherited inactivating mutations in DNA MMR genes are cau...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Houlleberghs, Hellen, Dekker, Marleen, Lantermans, Hildo, Kleinendorst, Roos, Dubbink, Hendrikus Jan, Hofstra, Robert M. W., Verhoef, Senno, te Riele, Hein
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839441/
https://ncbi.nlm.nih.gov/pubmed/26951660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520813113
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