Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants

Single-stranded DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high precision. We show that “oligo targeting” can be used effectively to study missense mutations in DNA mismatch repair (MMR) genes. Inherited inactivating mutations in DNA MMR genes are cau...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Houlleberghs, Hellen, Dekker, Marleen, Lantermans, Hildo, Kleinendorst, Roos, Dubbink, Hendrikus Jan, Hofstra, Robert M. W., Verhoef, Senno, te Riele, Hein
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839441/
https://ncbi.nlm.nih.gov/pubmed/26951660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520813113
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