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Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu(1)), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu(1) Receptors Found in Schizophrenics
The therapeutic potential of selective mGlu(1) activation is vastly unexplored relative to the other group I mGlu receptor, mGlu(5); therefore, our lab has focused considerable effort toward developing mGlu(1) positive allosteric modulators (PAMs) suitable as in vivo proof of concept tool compounds....
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| Gepubliceerd in: | J Med Chem |
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| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4839290/ https://ncbi.nlm.nih.gov/pubmed/26426481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00727 |
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