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Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.

Mammalian genomes are threatened with gene inactivation and chromosomal scrambling by recombination between repeated sequences such as mobile genetic elements and pseudogenes. We present and test a model for a defensive strategy based on the methylation and subsequent mutation of CpG dinucleotides i...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kricker, M C, Drake, J W, Radman, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48388/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1736289/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.3.1075
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