BET bromodomain inhibition releases the Mediator complex from select cis-regulatory elements

The bromodomain and extraterminal (BET) protein BRD4 can physically interact with the Mediator complex, but the relevance of this association to the therapeutic effects of BET inhibitors in cancer is unclear. Here, we show that BET inhibition causes a rapid release of Mediator from a subset of cis-r...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Bhagwat, Anand S., Roe, Jae-Seok, Mok, Beverly A., Hohmann, Anja F., Shi, Junwei, Vakoc, Christopher R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838499/
https://ncbi.nlm.nih.gov/pubmed/27068464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.054
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