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Detrimental effects of adenosine signaling in sickle cell disease
Hypoxia can act as an initial trigger to induce erythrocyte sickling and eventual end organ damage in sickle cell disease (SCD). Many factors and metabolites are altered in response to hypoxia and may contribute to the pathogenesis of the disease. Using metabolomic profiling, we found that the stead...
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| 發表在: | Nat Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838392/ https://ncbi.nlm.nih.gov/pubmed/21170046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2280 |
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