Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression

Priapism is featured with prolonged and painful penile erection and is prevalent among males with sickle cell disease (SCD). The disorder is a dangerous urological and hematological emergency since it is associated with ischemic tissue damage and erectile disability. Here we report that phosphodiest...

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Detalhes bibliográficos
Main Authors: Ning, Chen, Wen, Jiaming, Zhang, Yujin, Dai, Yingbo, Wang, Wei, Zhang, Weiru, Qi, Lin, Grenz, Almut, Eltzschig, Holger K., Blackburn, Michael R., Kellems, Rodney E., Xia, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021439/
https://ncbi.nlm.nih.gov/pubmed/24614760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247833
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