ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma

TP63, a member of the p53 gene family gene, encodes the ΔNp63 protein and is one of the most frequently amplified genes in squamous cell carcinomas (SCC) of the head and neck (HNSCC) and lungs (LUSC). Using an epiallelic series of siRNAs with intrinsically different knockdown abilities, we show that...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bretz, Anne Catherine, Gittler, Miriam P., Charles, Joël P., Gremke, Niklas, Eckhardt, Ines, Mernberger, Marco, Mandic, Robert, Thomale, Jürgen, Nist, Andrea, Wanzel, Michael, Stiewe, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838363/
https://ncbi.nlm.nih.gov/pubmed/26819410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw036
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