ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma

TP63, a member of the p53 gene family gene, encodes the ΔNp63 protein and is one of the most frequently amplified genes in squamous cell carcinomas (SCC) of the head and neck (HNSCC) and lungs (LUSC). Using an epiallelic series of siRNAs with intrinsically different knockdown abilities, we show that...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Bretz, Anne Catherine, Gittler, Miriam P., Charles, Joël P., Gremke, Niklas, Eckhardt, Ines, Mernberger, Marco, Mandic, Robert, Thomale, Jürgen, Nist, Andrea, Wanzel, Michael, Stiewe, Thorsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838363/
https://ncbi.nlm.nih.gov/pubmed/26819410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw036
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