c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements.

Glucose is known to increase the cAMP concentration in pancreatic beta cells. To determine the mechanism by which cAMP augments insulin gene expression, we first identified the cAMP response elements (CREs) of the human insulin gene. In DNase I footprint analysis, the bacterially synthesized CRE-bin...

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Библиографические подробности
Главные авторы: Inagaki, N, Maekawa, T, Sudo, T, Ishii, S, Seino, Y, Imura, H
Формат: Artigo
Язык:Inglês
Опубликовано: 1992
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC48382/
https://ncbi.nlm.nih.gov/pubmed/1310538
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