c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements.

Glucose is known to increase the cAMP concentration in pancreatic beta cells. To determine the mechanism by which cAMP augments insulin gene expression, we first identified the cAMP response elements (CREs) of the human insulin gene. In DNase I footprint analysis, the bacterially synthesized CRE-bin...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Inagaki, N, Maekawa, T, Sudo, T, Ishii, S, Seino, Y, Imura, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48382/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1310538/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.3.1045
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