Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats

Reactive oxygen species (ROS), originating predominantly from vascular smooth muscle cells (VSMCs), lead to vascular damage and endothelial dysfunction in rats with hypertension. The downstream signaling pathways of farnesyl pyrophosphate (FPP) synthase, Ras-related C3 botulinum toxin substrate 1 (R...

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Bibliographic Details
Published in:Mol Med Rep
Main Authors: HAN, JIE, JIANG, DONG-MEI, YE, YANG, DU, CHANG-QING, YANG, JIAN, HU, SHEN-JIANG
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2016
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838142/
https://ncbi.nlm.nih.gov/pubmed/27035426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2016.5025
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