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Increased Orexin Expression Promotes Sleep/Wake Disturbances in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis

BACKGROUND: Sleep/wake disturbances in patients with amyotrophic lateral sclerosis (ALS) are well-documented, however, no animal or mechanistic studies on these disturbances exist. Orexin is a crucial neurotransmitter in promoting wakefulness in sleep/wake regulation, and may play an important role...

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Detalhes bibliográficos
Publicado no:Chin Med J (Engl)
Main Authors: Liu, Rong, Sheng, Zhao-Fu, Cai, Bing, Zhang, Yong-He, Fan, Dong-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837845/
https://ncbi.nlm.nih.gov/pubmed/25591569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0366-6999.149214
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