The Structure-Activity Relationship of PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors for Non-Viral Gene Delivery

PEGylated polylysine peptides of the general structure PEG(30kDa)-Cys-Trp-Lys (N =10 to 30) were used to form fully condensed plasmid DNA (pGL3) polyplexes at a ratio of 1 nmol of peptide per μg of DNA (ranging from N:P 3:1 to 10:1 depending on Lys repeat). Co-administration of 5 to 80 nmols of exce...

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Vydáno v:Mol Pharm
Hlavní autoři: Baumhover, Nicholas J., Duskey, Jason T., Khargharia, Sanjib, White, Christopher W., Crowley, Samuel T., Allen, Rondine J., Rice, Kevin G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837691/
https://ncbi.nlm.nih.gov/pubmed/26485572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00513
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