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Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity
The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411V(Δ1–11)) in complex with xanthine. UapA is formed from two domains, a core...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4837479/ https://ncbi.nlm.nih.gov/pubmed/27088252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11336 |
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