Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines

AIM: To study the effect of anti-copper treatment for survival of hepatic cells expressing different ATP7B mutations in cell culture. METHODS: The most common Wilson disease (WD) mutations p.H1069Q, p.R778L and p.C271*, found in the ATP7B gene encoding a liver copper transporter, were studied. The m...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Chandhok, Gursimran, Horvath, Judit, Aggarwal, Annu, Bhatt, Mohit, Zibert, Andree, Schmidt, Hartmut HJ
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2016
Subjects:
Basic Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837429/
https://ncbi.nlm.nih.gov/pubmed/27122662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v22.i16.4109
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