Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5

The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly conserved 3′- and 5′-ends of the vRNA segment. The...

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Vydáno v:Sci Rep
Hlavní autoři: Swale, Christopher, Monod, Alexandre, Tengo, Laura, Labaronne, Alice, Garzoni, Frédéric, Bourhis, Jean-Marie, Cusack, Stephen, Schoehn, Guy, Berger, Imre, Ruigrok, Rob WH, Crépin, Thibaut
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837377/
https://ncbi.nlm.nih.gov/pubmed/27095520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24727
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