A Rat Model of Alzheimer’s Disease Based on Abeta(42) and Pro-oxidative Substances Exhibits Cognitive Deficit and Alterations in Glutamatergic and Cholinergic Neurotransmitter Systems

Alzheimer’s disease (AD) is one of the most serious human, medical, and socioeconomic burdens. Here we tested the hypothesis that a rat model of AD (Samaritan; Taconic Pharmaceuticals, USA) based on the application of amyloid beta(42) (Abeta(42)) and the pro-oxidative substances ferrous sulfate hept...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Petrasek, Tomas, Skurlova, Martina, Maleninska, Kristyna, Vojtechova, Iveta, Kristofikova, Zdena, Matuskova, Hana, Sirova, Jana, Vales, Karel, Ripova, Daniela, Stuchlik, Ales
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837344/
https://ncbi.nlm.nih.gov/pubmed/27148049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2016.00083
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