Toxicity of (neo)adjuvant chemotherapy for BRCA1- and BRCA2-associated breast cancer

Treatment with (neo)adjuvant chemotherapy for breast cancer, as currently given, causes cell damage by induction of double-strand DNA breaks. Because BRCA1 and BRCA2 proteins play a role in the repair of DNA damage, the efficacy of (neo)adjuvant chemotherapy may be increased in BRCA1/2-associated br...

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Enregistré dans:
Détails bibliographiques
Publié dans:Breast Cancer Res Treat
Auteurs principaux: Drooger, Jan C., Heemskerk-Gerritsen, Bernadette A. M., Smallenbroek, Nyrée, Epskamp, Cynthia, Seynaeve, Caroline M., Jager, Agnes
Format: Artigo
Langue:Inglês
Publié: Springer US 2016
Sujets:
Epidemiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837227/
https://ncbi.nlm.nih.gov/pubmed/27060914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-016-3777-0
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