Antagonism of Stem Cell Factor/c-kit Signaling Attenuates Neonatal Chronic Hypoxia-Induced Pulmonary Vascular Remodeling

BACKGROUND: Accumulating evidence suggests that c-kit positive cells are present in the remodeled pulmonary vasculature bed of patients with pulmonary hypertension (PH). Whether stem cell factor (SCF)/ c-kit regulated pathways potentiate pulmonary vascular remodeling is unknown. Here, we tested the...

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Bibliografiske detaljer
Udgivet i:Pediatr Res
Main Authors: Young, Karen C, Torres, Eneida, Hehre, Dorothy, Wu, Shu, Suguihara, Cleide, Hare, Joshua M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837030/
https://ncbi.nlm.nih.gov/pubmed/26705118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2015.275
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