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Transcription Factor Pax6 Contributes to Induction of GLT-1 Expression in Astrocytes Through an Interaction with a Distal Enhancer Element

The Na(+)-dependent glutamate transporter, GLT-1 (EAAT2), shows selective expression in astrocytes, and neurons induce expression of GLT-1 in astrocytes. In unpublished analyses of GLT-1 promoter reporter mice, we identified an evolutionarily conserved domain of 467 nucleotides ~8 kb upstream of the...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Ghosh, Mausam, Lane, Meredith, Krizman, Elizabeth, Sattler, Rita, Rothstein, Jeffrey D., Robinson, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837027/
https://ncbi.nlm.nih.gov/pubmed/26485579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13406
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