S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure

Cardiac myosin-binding protein C (cMyBP-C) regulates actin–myosin interaction and thereby cardiac myocyte contraction and relaxation. This physiologic function is regulated by cMyBP-C phosphorylation. In our study, reduced site-specific cMyBP-C phosphorylation coincided with increased S-glutathiolat...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Stathopoulou, Konstantina, Wittig, Ilka, Heidler, Juliana, Piasecki, Angelika, Richter, Florian, Diering, Simon, van der Velden, Jolanda, Buck, Friedrich, Donzelli, Sonia, Schröder, Ewald, Wijnker, Paul J. M., Voigt, Niels, Dobrev, Dobromir, Sadayappan, Sakthivel, Eschenhagen, Thomas, Carrier, Lucie, Eaton, Philip, Cuello, Friederike
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836368/
https://ncbi.nlm.nih.gov/pubmed/26839380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500048
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