The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is necessary for viral activation and infectivity. In humans and mice, members of the type II transmembrane protease family (TTSP), e.g., TMPRSS2, TMPRSS4, and TMPRSS11d (HAT), have been shown to cleave influenza virus HA for vira...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kühn, Nora, Bergmann, Silke, Kösterke, Nadine, Lambertz, Ruth L. O., Keppner, Anna, van den Brand, Judith M. A., Pöhlmann, Stefan, Weiß, Siegfried, Hummler, Edith, Hatesuer, Bastian, Schughart, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836353/
https://ncbi.nlm.nih.gov/pubmed/26889029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02693-15
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