A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of Porcine Reproductive and Respiratory Syndrome Virus nsp11

Porcine reproductive and respiratory syndrome virus (PRRSV) RNA endoribonuclease nsp11 belongs to the XendoU superfamily and plays a crucial role in arterivirus replication. Here, we report the first crystal structure of the arterivirus nsp11 protein from PRRSV, which exhibits a unique structure and...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Shi, Yuejun, Li, Youwen, Lei, Yingying, Ye, Gang, Shen, Zhou, Sun, Limeng, Luo, Rui, Wang, Dang, Fu, Zhen F., Xiao, Shaobo, Peng, Guiqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836315/
https://ncbi.nlm.nih.gov/pubmed/26912626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03065-15
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