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Analysis of Subcellular RNA Fractions Revealed a Transcription-Independent Effect of Tumor Necrosis Factor Alpha on Splicing, Mediated by Spt5

The proinflammatory cytokine tumor necrosis factor alpha (TNF-α) modulates the expression of many genes, primarily through activation of NF-κB. Here, we examined the global effects of the elongation factor Spt5 on nascent and mature mRNAs of TNF-α-induced cells using chromatin and cytosolic subcellu...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Diamant, Gil, Eisenbaum, Tal, Leshkowitz, Dena, Dikstein, Rivka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836220/
https://ncbi.nlm.nih.gov/pubmed/26903558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01117-15
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