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Is There Potential to Target FOXM1 for “Undruggable” Lung Cancers?

Published studies with transgenic mice convincingly showed that FOXM1 transcription factor is an important component of the KRAS/ERK signaling pathway in respiratory epithelial cells. FOXM1 is required for oncogenic KRAS signaling in mouse lung cancer models and therefore, clear potential exists to...

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Foilsithe in:Expert Opin Ther Targets
Main Authors: Kalinichenko, Vladimir V., Kalin, Tanya V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836176/
https://ncbi.nlm.nih.gov/pubmed/25936405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2015.1042366
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