HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

BACKGROUND: Bruton’s tyrosine kinase (Btk) is critical for activation of B cells and myeloid cells. This study aimed to characterize the effects of HM71224, a novel Btk inhibitor, both in vitro and in a mouse model of experimental arthritis. METHODS: The kinase inhibition profile of HM71224 was anal...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Park, Jin Kyun, Byun, Joo-Yun, Park, Ji Ah, Kim, Yu-Yon, Lee, Ye Ji, Oh, Jeong In, Jang, Sun Young, Kim, Young Hoon, Song, Yeong Wook, Son, Jeewoong, Suh, Kwee Hyun, Lee, Young-Mi, Lee, Eun Bong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835877/
https://ncbi.nlm.nih.gov/pubmed/27090981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0988-z
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